Isocitrate as Calcium Ion Activity Buffer in Coagulation Assays

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Isocitrate as calcium ion activity buffer in coagulation assays.

BACKGROUND Ca(2+) activity close to the physiological concentration of 1.3 mmol/L is essential in blood coagulation. Is this also true for the performance of global diagnostic coagulation assays? We searched for compounds that would buffer Ca(2+) activity at approximately 1.3 mmol/L without disturbing coagulation reactions and investigated whether such Ca(2+) buffering improves diagnostic effic...

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ژورنال

عنوان ژورنال: Clinical Chemistry

سال: 1999

ISSN: 0009-9147,1530-8561

DOI: 10.1093/clinchem/45.8.1176